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Graphical presentation of CX-5461-mediated activation of your cytosolic DNA sensing pathway. cGAS binding into the cytosolic DNA activates the secondary messenger 2,three-cGAMP working with cGAS as a catalyst. Activated STING buds off the ER going towards the perinuclear Golgi, wherever it can be palmitoylated.[167] The Boulton Paul Defiant, In spi